Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.9
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
L-Glutathione(reduced) (Free Form)
250 mg
**
Top Medical Research Studies
8
We examined how Mogroside V (MV), a natural compound, may protect the liver from damage caused by acetaminophen (APAP). In our study, mice were split into three groups: a control group, an APAP-only group, and an APAP group that also received MV.
Results showed that MV significantly reduced liver injury from APAP by decreasing harmful reactive oxygen species (ROS) and blocking a specific signaling pathway linked to cell death. These findings suggest MV could be a promising treatment to alleviate acetaminophen-induced liver toxicity.
Results showed that MV significantly reduced liver injury from APAP by decreasing harmful reactive oxygen species (ROS) and blocking a specific signaling pathway linked to cell death. These findings suggest MV could be a promising treatment to alleviate acetaminophen-induced liver toxicity.
Read More
8
We investigated whether reduced glutathione (GSH) could enhance the success of stem cell transplants in liver disease by targeting specific biological pathways. Our study focused on male mice with liver fibrosis, using GSH alongside other treatments during the transplant procedure.
The results showed that GSH significantly improved the efficiency of stem cell engraftment, likely by lowering oxidative stress in the liver. However, when combined with other drugs, the benefits were diminished. Overall, GSH presents a promising method to potentially improve treatments for liver fibrosis through its effects on stem cells.
The results showed that GSH significantly improved the efficiency of stem cell engraftment, likely by lowering oxidative stress in the liver. However, when combined with other drugs, the benefits were diminished. Overall, GSH presents a promising method to potentially improve treatments for liver fibrosis through its effects on stem cells.
Read More
8
We explored the effects of ACT001 on metabolic associated fatty liver disease (MAFLD) in a study involving mice. By analyzing transcriptomic and metabolomic data, we measured liver enzymes and lipid levels, finding that ACT001 significantly reduced both.
We noticed that it not only alleviated signs of liver damage but also influenced key metabolic pathways, including those related to glutathione. Our results suggest that ACT001 holds promise as a treatment for MAFLD, showing biological mechanisms that support its therapeutic effects.
We noticed that it not only alleviated signs of liver damage but also influenced key metabolic pathways, including those related to glutathione. Our results suggest that ACT001 holds promise as a treatment for MAFLD, showing biological mechanisms that support its therapeutic effects.
Read More
Most Useful Reviews
7.5
Detoxifying alternative
46 people found this helpful
Glutathione is a powerful detoxifier and antioxidant within our body. It binds numerous toxins and free radicals, thereby improving liver function. This is particularly relevant now, as it effectively restores the body after Covid. While glutathione drips are more potent, they aren't cheap. Thus, this option serves as a great alternative, albeit with a slower supportive effect. Additionally, taking NAC (n-acetylcysteine) several times a year is recommended since it contains the amino acid cysteine, a precursor of glutathione. Should my review prove helpful, please like it!
Read More
9
More energy experienced
2 people found this helpful
I tried Solgar's Reconstituted L-Glutathione and found it remarkably effective in supporting liver health and overall immunity. After consistent use, I've had increased energy levels and stress reduction. Additionally, I appreciate that these are vegan-friendly vegetable capsules, and there have been no unpleasant side effects. I feel better every day.
Read More
9
Fatty liver improvement
Combining this with Solgar's anti-fatty liver factor has effectively improved my fatty liver condition.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
- All Researches
8
We explored the effects of ACT001 on metabolic associated fatty liver disease (MAFLD) in a study involving mice. By analyzing transcriptomic and metabolomic data, we measured liver enzymes and lipid levels, finding that ACT001 significantly reduced both.
We noticed that it not only alleviated signs of liver damage but also influenced key metabolic pathways, including those related to glutathione. Our results suggest that ACT001 holds promise as a treatment for MAFLD, showing biological mechanisms that support its therapeutic effects.
We noticed that it not only alleviated signs of liver damage but also influenced key metabolic pathways, including those related to glutathione. Our results suggest that ACT001 holds promise as a treatment for MAFLD, showing biological mechanisms that support its therapeutic effects.
Read More
8
We examined how Mogroside V (MV), a natural compound, may protect the liver from damage caused by acetaminophen (APAP). In our study, mice were split into three groups: a control group, an APAP-only group, and an APAP group that also received MV.
Results showed that MV significantly reduced liver injury from APAP by decreasing harmful reactive oxygen species (ROS) and blocking a specific signaling pathway linked to cell death. These findings suggest MV could be a promising treatment to alleviate acetaminophen-induced liver toxicity.
Results showed that MV significantly reduced liver injury from APAP by decreasing harmful reactive oxygen species (ROS) and blocking a specific signaling pathway linked to cell death. These findings suggest MV could be a promising treatment to alleviate acetaminophen-induced liver toxicity.
Read More
8
We investigated whether reduced glutathione (GSH) could enhance the success of stem cell transplants in liver disease by targeting specific biological pathways. Our study focused on male mice with liver fibrosis, using GSH alongside other treatments during the transplant procedure.
The results showed that GSH significantly improved the efficiency of stem cell engraftment, likely by lowering oxidative stress in the liver. However, when combined with other drugs, the benefits were diminished. Overall, GSH presents a promising method to potentially improve treatments for liver fibrosis through its effects on stem cells.
The results showed that GSH significantly improved the efficiency of stem cell engraftment, likely by lowering oxidative stress in the liver. However, when combined with other drugs, the benefits were diminished. Overall, GSH presents a promising method to potentially improve treatments for liver fibrosis through its effects on stem cells.
Read More
8
We explored the effects of Total Sanghuangporus vaninii extract (TSH) on liver fibrosis using a mouse model. Through rigorous analysis, we observed that TSH significantly protects against liver damage caused by carbon tetrachloride.
It not only reduces harmful liver cell death but also inhibits the activation of liver star cells and collagen buildup. Additionally, TSH positively influences gut health by modifying gut microbiota, which may further help in alleviating liver fibrosis.
Overall, our findings highlight TSH as a promising candidate for liver disease management.
It not only reduces harmful liver cell death but also inhibits the activation of liver star cells and collagen buildup. Additionally, TSH positively influences gut health by modifying gut microbiota, which may further help in alleviating liver fibrosis.
Overall, our findings highlight TSH as a promising candidate for liver disease management.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Detoxifying alternative
46 people found this helpful
Glutathione is a powerful detoxifier and antioxidant within our body. It binds numerous toxins and free radicals, thereby improving liver function. This is particularly relevant now, as it effectively restores the body after Covid. While glutathione drips are more potent, they aren't cheap. Thus, this option serves as a great alternative, albeit with a slower supportive effect. Additionally, taking NAC (n-acetylcysteine) several times a year is recommended since it contains the amino acid cysteine, a precursor of glutathione. Should my review prove helpful, please like it!
Read More
9
More energy experienced
2 people found this helpful
I tried Solgar's Reconstituted L-Glutathione and found it remarkably effective in supporting liver health and overall immunity. After consistent use, I've had increased energy levels and stress reduction. Additionally, I appreciate that these are vegan-friendly vegetable capsules, and there have been no unpleasant side effects. I feel better every day.
Read More
9
Fatty liver improvement
Combining this with Solgar's anti-fatty liver factor has effectively improved my fatty liver condition.
Read More
6
Complexion improved
5 people found this helpful
Excellent! After learning that glutathione aids in removing toxins and cleansing the liver, I opted to take it for three months. Although I've only been drinking it for a month, I noticed improved complexion and reduced pore visibility after just ten days. Maintaining proper hydration is essential.
Read More
6
Energy boost observed
3 people found this helpful
Since initiating the intake, I've experienced morning bitterness in my mouth, a sign of liver cleansing. My mood has improved, and my energy levels have increased as a result.
Read More
Frequently Asked Questions
7.5
Notable improvement
1 people found this helpful
Appointed by a gastroenterologist to treat liver disease, this medication works. I noticed an improvement in my well-being within just 1-2 weeks of taking it.
7.5
Pigmentation reduced
I took this to support my liver and eliminate pigmentation, combining it with other vitamins. My skin has significantly improved, and the yellowness has vanished. It's essential to take it in long courses—about three months—alongside nutritious products.
6
Complexion improved
5 people found this helpful
Excellent! After learning that glutathione aids in removing toxins and cleansing the liver, I opted to take it for three months. Although I've only been drinking it for a month, I noticed improved complexion and reduced pore visibility after just ten days. Maintaining proper hydration is essential.
9
More energy experienced
2 people found this helpful
I tried Solgar's Reconstituted L-Glutathione and found it remarkably effective in supporting liver health and overall immunity. After consistent use, I've had increased energy levels and stress reduction. Additionally, I appreciate that these are vegan-friendly vegetable capsules, and there have been no unpleasant side effects. I feel better every day.
6
Energy boost observed
3 people found this helpful
Since initiating the intake, I've experienced morning bitterness in my mouth, a sign of liver cleansing. My mood has improved, and my energy levels have increased as a result.
9
Fatty liver improvement
Combining this with Solgar's anti-fatty liver factor has effectively improved my fatty liver condition.
7.5
Detoxifying alternative
46 people found this helpful
Glutathione is a powerful detoxifier and antioxidant within our body. It binds numerous toxins and free radicals, thereby improving liver function. This is particularly relevant now, as it effectively restores the body after Covid. While glutathione drips are more potent, they aren't cheap. Thus, this option serves as a great alternative, albeit with a slower supportive effect. Additionally, taking NAC (n-acetylcysteine) several times a year is recommended since it contains the amino acid cysteine, a precursor of glutathione. Should my review prove helpful, please like it!
6
Super remedy found
1 people found this helpful
This supplement is fantastic, but remember to take it in monthly courses. One tablet on an empty stomach in the morning acts as a liver supplement, enhancing energy levels.
8
We explored the effects of ACT001 on metabolic associated fatty liver disease (MAFLD) in a study involving mice. By analyzing transcriptomic and metabolomic data, we measured liver enzymes and lipid levels, finding that ACT001 significantly reduced both.
We noticed that it not only alleviated signs of liver damage but also influenced key metabolic pathways, including those related to glutathione. Our results suggest that ACT001 holds promise as a treatment for MAFLD, showing biological mechanisms that support its therapeutic effects.
We noticed that it not only alleviated signs of liver damage but also influenced key metabolic pathways, including those related to glutathione. Our results suggest that ACT001 holds promise as a treatment for MAFLD, showing biological mechanisms that support its therapeutic effects.
8
We examined how Mogroside V (MV), a natural compound, may protect the liver from damage caused by acetaminophen (APAP). In our study, mice were split into three groups: a control group, an APAP-only group, and an APAP group that also received MV.
Results showed that MV significantly reduced liver injury from APAP by decreasing harmful reactive oxygen species (ROS) and blocking a specific signaling pathway linked to cell death. These findings suggest MV could be a promising treatment to alleviate acetaminophen-induced liver toxicity.
Results showed that MV significantly reduced liver injury from APAP by decreasing harmful reactive oxygen species (ROS) and blocking a specific signaling pathway linked to cell death. These findings suggest MV could be a promising treatment to alleviate acetaminophen-induced liver toxicity.
8
We explored the effects of Total Sanghuangporus vaninii extract (TSH) on liver fibrosis using a mouse model. Through rigorous analysis, we observed that TSH significantly protects against liver damage caused by carbon tetrachloride.
It not only reduces harmful liver cell death but also inhibits the activation of liver star cells and collagen buildup. Additionally, TSH positively influences gut health by modifying gut microbiota, which may further help in alleviating liver fibrosis.
Overall, our findings highlight TSH as a promising candidate for liver disease management.
It not only reduces harmful liver cell death but also inhibits the activation of liver star cells and collagen buildup. Additionally, TSH positively influences gut health by modifying gut microbiota, which may further help in alleviating liver fibrosis.
Overall, our findings highlight TSH as a promising candidate for liver disease management.
References
- Liu J, Zhou Y, Li Y, Chen Z, Jiao X, et al. Integrative transcriptomic and metabolomic analysis explores the mechanisms by which ACT001 treats MAFLD in mice. Sci Rep. 2025;15:12494. doi:10.1038/s41598-025-97312-9
- Shi JL, Sun T, Li Q, Li CM, Jin JF, et al. Mogroside V protects against acetaminophen-induced liver injury by reducing reactive oxygen species and c-jun-N-terminal kinase activation in mice. World J Hepatol. 2025;17:104520. doi:10.4254/wjh.v17.i3.104520
- Yu S, Wang Y, Shi Y, Yu S, Zhao B, et al. Reduced glutathione enhances adipose tissue-derived mesenchymal stem cell engraftment efficiency for liver fibrosis by targeting TGFβ1/SMAD3/NOX4 pathway. Bioeng Transl Med. 2025;10:e10735. doi:10.1002/btm2.10735
- Gao S, Wang X, Xu Q, Li R, Yao L, et al. Total Sanghuangporus vaninii extract inhibits hepatocyte ferroptosis and intestinal microbiota disturbance to attenuate liver fibrosis in mice. J Ethnopharmacol. 2025;345:119571. doi:10.1016/j.jep.2025.119571
